Symbol
Name
ID

Wfs1
wolframin ER transmembrane glycoprotein
MGI:1328355

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Stroke-like episode

Dysphagia

Abnormal amplitude of pattern reversal visual evoked potentials

Spasticity

Spastic paraplegia

Basal ganglia calcification

Atrophy/Degeneration affecting the brainstem

Cerebral cortical atrophy

Corpus callosum atrophy

Abnormal periventricular white matter morphology

Cerebral atrophy

Cerebellar atrophy

Ataxia

Tremor

Hemiparesis

Dysarthria

Depression

Anxiety

Psychosis

Schizophrenia

Hallucinations

Atypical behavior

Autism

Polydipsia

Polyphagia

Cognitive impairment

Dementia

Intellectual disability

Sleep abnormality

Areflexia

Gait disturbance

Migraine

Developmental regression

Global developmental delay

Peripheral neuropathy

Sensorimotor neuropathy

Seizure

Abnormal autonomic nervous system physiology

Disease(s) Associated with WFS1

autosomal dominant Wolfram syndrome

optic atrophy

optic atrophy 1

type 1 diabetes mellitus

Wolfram syndrome

Wolfram syndrome 1

Mouse Phenotypes		nervous system phenotype	abnormal inner hair cell stereociliary bundle morphology	fused inner hair cell stereocilia	absent outer hair cell stereocilia	cochlear outer hair cell degeneration	fused vestibular hair cell stereocilia	vestibular hair cell degeneration
Availability	Mouse Genotype	nervous system phenotype	abnormal inner hair cell stereociliary bundle morphology	fused inner hair cell stereocilia	absent outer hair cell stereocilia	cochlear outer hair cell degeneration	fused vestibular hair cell stereocilia	vestibular hair cell degeneration
	Wfs1^tm1.1Bedel/Wfs1^tm1.1Bedel	*
	Wfs1^tm1Koks/Wfs1^tm1Koks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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